WebJan 1, 2006 · A novel apoptosis inducer, thioviridamide, was isolated from an actinomycete identified as Streptomyces olivoviridis. The molecular formula of thioviridamide was … Webof thioamitides display potent cytotoxic activity by inhibiting mito-chondrial ATP synthase, which leads to mitochondrial dysfunction and in turn triggers apoptosis.4-6 The founding member of this group, thioviridamide, was isolated from Streptomyces olivoviridis NA005001,7 and the identification of its biosynthetic gene cluster
Biochemical Reconstitution Reveals the Biosynthetic Timing and ...
WebThe thioamitides are one of the most structurally complex RiPP families, yet very few thioamitide biosynthetic steps have been elucidated, even though the gene clusters of multiple thioamitides ... WebOct 17, 2024 · Here, we report a scalable platform that combines high-throughput bioinformatics with automated biosynthetic gene cluster refactoring for rapid evaluation of uncharacterized gene clusters. As a proof of concept, 96 RiPP gene clusters that originate from diverse bacterial phyla involving 383 biosynthetic genes are refactored in a high … hard seltzer with most alcohol
Angewandte Chemie International Edition - Wiley Online …
WebOct 16, 2024 · The Utilization of Lanthipeptide Synthetases Is a General Strategy for the Biosynthesis of 2-Aminovinyl-Cysteine Motifs in Thioamitides ** Webnoun. thio· amide -ˈam-ˌīd, -əd. : an amide of a thio acid. especially : an amide having the general formula RCSNH2. WebFocusing on the hdmHis residue that is unique to thioamitides, we report the enzymatic process for His functionalization and, more importantly, the timing of its related reactions with the other ... change is beautiful