WebCentral pontine myelinolysis (CPM) is a rare demyelinating condition of the pons affecting: long tract fibres; pontocerebellar fibres; pontine nuclei; CPM is associated with: chronic … WebFeb 5, 2024 · Introduction. Central pontine myelinolysis (CPM) is a component of osmotic demyelination syndrome (ODS). It is characterized by damage to regions of the brain, …
Central Pontine Myelinolysis - an overview ScienceDirect Topics
WebCentral pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in … Central pontine myelinolysis; Other names: Osmotic demyelination syndrome, central pontine demyelination: Axial fat-saturated T2-weighted image showing hyperintensity in the pons with sparing of the peripheral fibers, the patient was an alcoholic admitted with a serum Na of 101 treated with hypertonic … See more Central pontine myelinolysis is a neurological condition involving severe damage to the myelin sheath of nerve cells in the pons (an area of the brainstem). It is predominately iatrogenic (treatment-induced), and is … See more The most common cause is overly-rapid correction of low blood sodium levels (hyponatremia). Apart from rapid correction of hyponatraemia, there are case reports of central pontine … See more It can be diagnosed clinically in the appropriate context, but may be difficult to confirm radiologically using conventional imaging techniques. Changes are more prominent on MRI … See more Though traditionally the prognosis is considered poor, a good functional recovery is possible. All patients at risk of developing refeeding syndrome should have their electrolytes closely monitored, including sodium, potassium, magnesium, glucose and … See more Symptoms depend on the regions of the brain involved. Prior to its onset, patients may present with the neurological signs and symptoms of hyponatraemic encephalopathy such as nausea and vomiting, confusion, headache and seizures. These … See more The currently accepted theory states that the brain cells adjust their osmolarities by changing levels of certain osmolytes like inositol See more To minimise the risk of this condition developing from its most common cause, overly rapid reversal of hyponatremia, the hyponatremia should be corrected at a rate not exceeding 10 mmol/L/24 h or 0.5 mEq/L/h; or 18 mEq/L/48hrs; thus avoiding demyelination. No … See more severe lesion in mid rca
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WebFeb 1, 2004 · Summary: Central pontine myelinolysis (CPM) occurs in the setting of rapidly corrected hyponatremia, especially in chronically debilitated patients. Conventional CT … WebCentral pontine myelinolysis is a concentrated, frequently symmetric, noninflammatory demyelination within the pons. The area involved is usually confined to the basal part of … WebOct 5, 2024 · Pontine and extrapontine myelinolysis can occur after the rapid correction of hyponatremia. In this disease, myelin and oligodendrocytes are damaged, while the neurons and axons are relatively spared [].The lesions occur symmetrically in the thalamus, pons, striatum, cerebral cortex, cerebellum and other areas [].Common clinical manifestations … severe leg pain when walking or standing