WebPalovarotene (Sohonos™) is an orally bioavailable selective retinoic acid receptor (RAR)γ agonist being developed by Ipsen for the reduction of heterotopic ossification (HO) formation in patients with fibrodysplasia ossificans progressiva (FOP). WebMar 26, 2024 · Palovarotene is a RARγ agonist being developed as a potential treatment for patients with ultra-rare and debilitating bone diseases, including fibrodysplasia ossificans progressiva (FOP) and multiple osteochondromas (MO), as well as other conditions including dry eye disease.
Ipsen receives Complete Response Letter for palovarotene, an ...
WebFeb 23, 2024 · Palovarotene overview. Palovarotene (Sohonos) is a member of the retinoid class of drugs that is associated with birth defects in humans. ... This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s … WebJan 27, 2024 · Palovarotene was acquired by Ipsen as part of its $1 billion upfront acquisition of Clementia Pharma in 2024, but almost immediately ran into trouble. It failed a futility test in a pivotal trial ... google search for similar websites
Palovarotene - Wikipedia
WebPalovarotene is a retinoic acid receptor gamma (RARγ) agonist licensed to Clementia Pharmaceuticals from Roche Pharmaceuticals. At Roche, palovarotene was evaluated in more than 800 individuals including healthy volunteers and patients with chronic obstructive pulmonary disease (COPD). [15] WebMedscape - Fibrodysplasia ossificans progressiva dosing for palovarotene, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. WebDec 23, 2024 · Palovarotene is seeking approval based on the open-label Phase 3 trial single-treatment arm trial in which all subjects receive palovarotene dosing in order to evaluate the safety and dosing regimen. The FDA postponed their adcomm meeting that was set for October 31 in order to review new information, which has the possibility to … google search for scholarly articles