WebNavitoclax is relatively well tolerated in patients, with thrombocytopenia reported as the major adverse effect (Gandhi et al., 2011). Investigators have begun testing these … Web8 de jun. de 2024 · Recapitulated in our mouse xenograft model, the combination inhibited tumor growth, reduced sphere-forming capacity (p < 0.01 and 0.05, respectively), and had tolerable toxicity (p > 0.40).
A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax
Web1 de jun. de 2012 · Results: The most common toxicity associated with navitoclax was thrombocytopenia, which reached grade III-IV in 41% of patients. Partial response was observed in one (2.6%) patient and stable disease in 9 (23%) patients. Median PFS was … Web29 de sept. de 2015 · Purpose Navitoclax (ABT-263), a novel, oral Bcl-2 inhibitor, enhances the antitumor effects of chemotherapy in vitro by lowering the apoptotic threshold. This phase I study (NCT01009073) evaluated the safety, pharmacokinetics, and preliminary antitumor activity of navitoclax combined with erlotinib in patients with advanced solid … henry garden centre reading
Combination Therapy of Navitoclax with Chemotherapeutic …
WebNavitoclax in combination with rituximab was well tolerated as initial therapy for patients with CLL, yielded higher response rates than rituximab alone and resulted … WebCombination therapy emerges as a fundamental scheme in cancer. Many targeted therapeutic agents are developed to be used with chemotherapy or radiation therapy to enhance drug efficacy and reduce toxicity effects. ABT-263, known as navitoclax, mimics the BH3-only proteins of the BCL-2 family and has a high affinity towards pro-survival … Web31 de ene. de 2011 · This is a mechanism-based toxicity induced by inhibition of Bcl-xL in circulating platelets, 13,18 which is required for platelet survival. 19,20 Here we describe a phase I dose-escalation study to evaluate the safety (with particular attention to platelet dynamics), pharmacokinetics, and preliminary efficacy of navitoclax administered on … henry gardens ottery st mary