WebDec 8, 2010 · One-pot generation of a (hydrido)silyl ether from the carbonyl compound or alcohol is followed by dehydrogenative cyclization at 80-100 °C in the presence of norbornene as a hydrogen acceptor and the combination of 1 mol % [Ir (cod)OMe]2 and 1,10-phenanthroline as a catalyst to form benzoxasiloles. WebLater, Hartwig and co-workers further applied this strategy to the iridium-catalyzed, β-C(sp 3)–H silylation of aliphatic amines to prepare 1,2-amino alcohols by utilizing a methylene linkage between the silyl group and nitrogen atom. 33 Enantiopure 1,2-amino alcohols could be furnished at or even below room temperature by employing electron ...
Publications The Hartwig Group
WebJun 19, 2012 · Based on this hypothesis, we studied catalysts containing substituted phenanthroline ligands for a series of additional transformations, including the silylation … WebHartwig, J.F. “Borylation and Silylation of C–H Bonds: A Platform for Diverse C–H Bond Functionalizations” Acct. Chem. Res. 2012, 45, 864–873 [doi ... publishing date of catcher in the rye
John F. Hartwig - Google Scholar
WebJul 14, 2024 · Troshin and Hartwig circumvented this problem by screening three pools of reagents in parallel that shared the same reactive functionality but differed in mass by carefully chosen increments. Specific products could then be identified in a noisy distribution by their distinctive expected mass differences across the three pools. WebHartwig, J.F., Romero, E.A. Iridium-catalyzed silylation of unactivated C-H bonds. Tetrahedron 2024 , 75 , 4059-4070. 406. Karmel, C., Chen, Z., Hartwig, J.F. Iridium-Catalyzed Silylation of C–H Bonds in Unactivated Arenes: A Sterically Encumbered Phenanthroline Ligand Accelerates Catalysis. J. Am. Chem. Soc. 2024 , 141 , 7063 … WebAngewandte Chemie International Edition Communication A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C−H Bonds Dr. Bo Su, Dr. Tai-Gang Zhou, Dr. Xian-Wei Li, Xiao-Ru Shao, Pei-Lin Xu, Dr. Wen-Lian Wu, Prof. Dr. John F. Hartwig, Prof. Dr. Zhang-Jie Shi First published: 15 December 2016 publishing date of crime and punishment