WebErythropoietin (EPO) and its receptor (EPOR), frequently overexpressed in breast cancer, are true targets of miR-125b. Report frequency of EPO SNPs in diabetic nephropathy. These findings provide a framework for understanding that production of high levels of EPO induced by hypoxia also involves regulation at the translational level. WebThe EPOR gene provides instructions for making a protein called the erythropoietin receptor. Erythropoietin is a hormone that directs the production of new red blood cells …

Erythropoietins: a common mechanism of action - PubMed

The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as … See more The cytoplasmic domains of the EpoR contain a number of phosphotyrosines that are phosphorylated by Jak2 and serve as docking sites for a variety of intracellular pathway activators and Stats (such as Stat5). … See more Mice with truncated EpoR are viable, which suggests Jak2 activity is sufficient to support basal erythropoiesis by activating the necessary pathways without phosphotyrosine … See more Erythropoietin receptor has been shown to interact with: • CRKL, • Erythropoietin, See more • Erythropoietin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine See more Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Overproduction of red blood cells increases a chance of adverse cardiovascular … See more • Zhu Y, D'Andrea AD (Mar 1994). "The molecular physiology of erythropoietin and the erythropoietin receptor". Current Opinion in … See more WebJul 24, 1998 · The crystal structure of erythropoietin complexed to the extracellular ligand-binding domains of the erythropoietin receptor, determined at 1.9 A from two crystal forms, shows that erythropoietin imposes a unique 120 degrees angular relationship and orientation that is responsible for optimal signalling through intracellular kinase pathways. kirin noodle bar columbus

Erythropoietin - Wikipedia

WebOct 10, 2006 · Binding of Epo to its homodimeric receptor and initiation of signal transduction. (A) Crystal structure of the complex of Epo with 2 extracellular domains of EpoR (from Syed et al). 11 Red cylinders denote α-helices and green ribbons denote β-sheets. For detailed information on interacting sites in the complex see Syed et al. 11 (B) … WebFeb 1, 2024 · Descriptions. Epoetin injection is a man-made version of human erythropoietin (EPO). EPO is produced naturally in the body, mostly by the kidneys. It … WebMar 31, 2024 · A role for tyrosine phosphorylation in the signal-transducing mechanisms of several hematopoietic growth factors has been hypothesized. To extend these observations, we have examined the effects of erythropoietin (Epo) on tyrosine phosphorylation in an Epo-responsive cell that was obtained by transfecting the murine erythropoietin … kirin peach tea soda