Cisplatin anticancer mechanism

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August undefined, 2024

WebApr 10, 2024 · The current study focuses on the Pd (II) and Pt (II) trinuclear chelates with spermidine (Pd 3 Spd 2 and Pt 3 Spd 2) and aims to evaluate its putative anticancer activity towards cisplatin-resistant TNBC cells (MDA-MB-231/R), as compared to cisplatin-sensitive TNBC (MDA-MB-231), by assessing the (i) antiproliferative activity, (ii) … Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water to give the aquo complex cis-[PtCl(NH3)2(H2O)] , in a process termed aquation. Dissociation of the chloride is favored inside the cell because the intracellular chloride concentration is only 3–20% of the approxi…

Cisplatin: The first metal based anticancer drug - PubMed

National Center for Biotechnology Information www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov WebApr 29, 2024 · In order to overcome cisplatin-resistance, seven cyclometalated ruthenium ( II) complexes were synthesized with a varying degree of fluorine substitution, for use as anticancer agents. A cytotoxicity assay testified that the complexes possessed a more cytotoxic effect than cisplatin towards the cisplatin-resistant cell line A549R. greenleaf flowlogic sign in

Cisplatin (Anti-cancer Drug) - SlideShare

WebMar 15, 2011 · Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased DNA repair. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. WebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA … fly from mia to cnf

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Cisplatin in cancer therapy: molecular mechanisms of action

WebOct 6, 2016 · Multiple mechanisms including tubular epithelial cell toxicity, vasoconstriction in the renal microvasculature and proinflammatory effects contribute to renal dysfunction following exposure to cisplatin. The mechanism of nephrotoxicity is associated with a chloride ion at the cis position of the drug. WebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response … greenleaffoods.com emailWebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … greenleaf flower shop west point ms

"WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … " - Cisplatin anticancer mechanism

Cisplatin anticancer mechanism

Biochemical mechanisms of cisplatin cytotoxicity - PubMed

WebA deep knowledge of the biochemical mechanisms, which are triggered in the tumor cell … WebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions …

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Web2 days ago · Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli. WebJul 1, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine …

WebJul 19, 2024 · The mechanisms of anti-cancer drugs brings together learning about transition metals, DNA and ethical considerations in science and medicine. This is an opportunity for cross-curricular debate within … Web1152 rows · Jun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Brand Names. …

WebJul 1, 2024 · Action mechanism of cisplatin anticancer activity. Cisplatin may also induce cell apoptosis from cell membrane [57]. The type II transmembrane protein and Fas … WebJun 20, 2024 · Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents employed today and is effective against a wide range of …

WebSep 18, 2024 · Cisplatin is an antineoplastic agent that came into use in the late 1970s. Cisplatin, while highly toxic, is one of the most heavily utilized chemotherapeutic agents for hematologic and solid tumor malignancies. …

Web2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid … green leaf flowers west point msWebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the bloodstream, it … greenleaf fontanet indianaWebCisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Although cisplatin, cis-diamminedichloroplatinum(II), has been successfully used in the chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still unclear. greenleaf florist west point msWeb2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … fly from miami to san juanWebCisplatin enters the cell either passively or through a transporter, where two water molecules replace the chloride groups. As an electrophile, cisplatin is attracted to the nitrogen on purine bases in the DNA, where it forms inter or intra-strand crosslinks, interrupting DNA repair and replication processes. greenleaf foaming hand soapWebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism by which resistance is reported to develop is a reduction in … fly from mia to riga airportWebJun 26, 2024 · The cytotoxic action of cisplatin is conditioned by the covalent binding of this molecule to N-7 purine atoms on high affinity DNA, which leads to the cross-link of DNA strands and inhibition of... green leaf flower plant